Acute Communicable
Disease Control

Contact Information
County of Los Angeles
Department of Public Health
Acute Communicable Disease Control
313 N. Figueroa Street, #212
Los Angeles, CA 90012
Phone: (213) 240-7941
Fax: (213) 482-4856

Call 211 For Information 24/7

Have questions about things like where to go for vaccinations or other health care services?

Call 2-1-1.

Adobe Reader

Note: PDF documents on this site were created using Adobe Acrobat 5.0 or later. If you are using an earlier version of Adobe Acrobat Reader (4.x or less), document functionality may be reduced.
Acute Communicable Disease Control

Carbapenemase-Producing Organisms (CPO)

CPOs are types of bacteria that produce a genetically-encoded antibiotic resistance mechanism called a carbapenemase. Carbapenemases allow bacteria to become resistant to carbapenems and other β-lactam antibiotics. The genes that encode carbapenemases are typically found on mobile gene elements called plasmids, which means they can be easily transferred between different types of bacteria. Thus, people who are infected or colonized with a CPO need a high level of adherence to infection control to prevent the spread of CPOs.



  • Carbapenemase-producing Organisms: Guidance for Reporting and Containment (9-29-22) slides  recording
  • Testing for Carbapenemase Production Among Carbapenem-Resistant Organisms: When and How? (10-27-22) slides  recording

CPO Patient Education


CPO Wallet Card: healthcare facilities can provide this to patients/residents that are infected/colonized with a CPO in order to remind them that they may need special precautions when receiving health care at a facility or at home.

PDF: English

Useful Links
LACDPH Monthly MDRO Lab Newsletter
LAC Carbapenemase Testing Explanation 2021
When Should Clinical Microbiology Laboratories Perform Carbapenemase Detection Tests? (CLSI)

Global Spread of Carbapenemase-producing Enterobacteriaceae (CDC)

Tracking CP-Carbapenem-Resistant Enterobacteriaceae in the US (CDC)

Tracking CP-Carbapenem-Resistant Pseudomonas aeruginosa in the US (CDC)

See Also
Antimicrobial Resistance
Carbapenem-Resistant Enterobacterales (CRE)

News Archive
CDC Travel Alert: Carbapenem-Resistant Pseudomonas aeruginosa Infections Following Invasive Medical Procedures in Tijuana, Mexico (1-14-19)

For questions, please email us at:br>

Healthcare Outreach
Public Health has made reasonable efforts to provide accurate translation. However, no computerized translation is perfect and is not intended to replace traditional translation methods. If questions arise concerning the accuracy of the information, please refer to the English edition of the website, which is the official version.
Los Angeles County Seal: Enriching lives through effective and caring services